Molecular Biology - Part 1: DNA Replication and Repair

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Обучение бесплатное
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Сертификация платная
Duration
2 месяца
О курсе

You’re acquainted with your DNA, but did you know that your cells synthesize enough DNA during your lifetime to stretch a lightyear in length? How does the cellular machinery accomplish such a feat without making more mistakes than you can survive? Why isn’t the incidence of cancer even higher than it is? And, if the DNA in each and every cell is two meters long, how is this genetic material compacted to fit inside the cell nucleus without becoming a tangled mess?

Are you ready to go beyond the “what" of scientific information presented in textbooks and explore how scientists deduce the details of these molecular models?

Take a behind-the-scenes look at modern molecular genetics, from the classic experimental events that identified the proteins involved in DNA replication and repair to cutting-edge assays that apply the power of genome sequencing. Do you feel confident in your ability to design molecular biology experiments and interpret data from them? We've designed the problems in this course to build your experimental design and data analysis skills.

Let’s explore the limits of our current knowledge about the replication machinery and pathways that protect the fidelity of DNA synthesis. If you are up for the challenge, join us in 7.28x Part 1: DNA Replication and Repair.

Follow the latest news from MITx Biology @MITxBio on Twitter .

Программа
Molecular Biology - Part 1: DNA Replication and Repair
An in-depth adventure through DNA replication and repair to strengthen your scientific thinking and experimental design skills.
Что Вы изучите?
  • How to compare and contrast the mechanisms of DNA replication in prokaryotes and eukaryotes
  • How to describe several enzymatic mechanisms that the cell uses to repair or tolerate DNA damage
  • How to analyze protein structures to infer functional information
  • How to designmethods for the best experiment to test a hypothesis related to DNA replication or repair proteins
  • How to interpret data from DNA replication and repair experiments
Лекторы
Stephen P. Bell
Stephen P. Bell
HHMI Investigator; Professor of Biology MIT
Steve Bell is a Professor of Biology in the Department of Biology at MIT and an HHMI Investigator. Steve and his lab study the regulation of eukaryotic replication using biochemical, genetic, and molecular biology approaches. He has received the institute-wide Everett Moore Baker Memorial Teaching Award as well as a School of Science Teaching Prize for Excellence in Undergraduate Education. Along with Tania, Steve co-authored a popular molecular biology textbook with James Watson.
Tania A. Baker
Tania A. Baker
HHMI Investigator; Whitehead Professor of Biology MIT
Tania Baker is an E. C. Whitehead Professor of Biology and an HHMI Investigator. Tania recently received the Arthur Kornberg and Paul Berg Lifetime Achievement Award for her research in replication and AAA+ unfoldases, which remove potentially toxic proteins. Tania has also been recognized for her commitment to teaching as a recipient of the Margaret MacVicar Faculty Fellowship and a School of Science Teaching Prize for Excellence in Undergraduate Education. In addition to authoring the textbook with Steve, as a graduate student, Tania co-authored a well-known textbook on DNA replication with Arthur Kornberg.
Mary Ellen Wiltrout
Mary Ellen Wiltrout
MITx Digital Learning Scientist, Department of Biology Massachusetts Institute of Technology
Dr. Mary Ellen Wiltrout is an MITx Digital Learning Scientist in the Department of Biology at MIT. She previously completed her Ph.D. in Graham Walker’s lab from the Department of Biology at MIT, taught molecular biology at Harvard University, and returned to MIT as a core development member of MITx 7.00x. She now oversees and manages all of the MITx projects for the Department of Biology at MIT.
Sera Thornton
Sera Thornton
MITx Digital Learning Fellow, Department of Biology Massachusetts Institute of Technology
Dr. Sera Thornton was an MITx Digital Learning Fellow in the Department of Biology at MIT from 2014 to 2017. In conjunction with her role as a core member of the MITx Biology course development team, Sera curated and created many of the graphics for MITx Biology courses, including animating the lecture video inserts for MITx 7.28x. She previously completed her Ph.D. studying epigenetic gene regulation in stem cell lineage commitment and differentiation in the Boyer lab at MIT.
Nathaniel Schafheimer
Nathaniel Schafheimer
MITx Digital Learning Fellow, Department of Biology MIT
Dr. Nathaniel Schafheimer was an MITx Digital Learning Fellow in the Department of Biology at MIT from 2013 to 2015. He had a central role in the development and management of the MITx courses for the Department of Biology at MIT. He previously completed his Ph.D. studying how ultraviolet light damages the proteins in the lens of the human eye in Jonathan King’s lab at MIT.
Платформа
EdX
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